Clinical research is an important component of our work in the University Malaya Division of Neurosurgery.
Our team is involved in a number of different types of research involving neurosurgical diseases and its management including pre-clinical laboratory research and translational research, as well as interventional and observational clinical trials and technological innovations in surgical practice and teaching.
We hope to identify better ways to diagnose, prognosticate and follow up our patients with brain disorders. We also look at optimising treatment in these patients to improve their quality of life as well as life expectancy.
Among our selected research work in the last 2 years include:
Research on Brain Tumors
Research on Traumatic Brain Injury
Research on Spine Surgery
Research on Surgical Innovation and Teaching
Research on Functional Surgery
Research on Skullbase Surgery
Research on Epilepsy Surgery
Research on Paediatric Neurosurgery
Research on Vascular Neurosurgery
Grants
Research on Brain Tumors
- Neural Fiber Integrity in High-Versus Low-Grade Glioma using Probabilistic Fiber Tracking. V Narayanan, AT Hernowo, NFA Bahuri, CY Chamet al. Academic Radiology 2020
- Lipid fraction derived from MRI in-and opposed-phase sequence as a novel biomarker for predicting survival outcome of glioma. V Narayanan, RJ Romelean, H Chandran et al. Academic radiology 2020
- A rare case of perivascular epithelioid cell tumour metastases to the brain. RR Jayapalan, NFA Bahuri, KS Mun, V Narayanan.SAGE Open Medical Case Reports 2019
- Single Port Endoscope-Assisted Excision of Forehead Lesions: An Innovative Way of Improving the Optical Cavity. V Narayanan, RR Jayapalan, AS Sidhu, KMR Koh.Journal of Craniofacial Surgery 2019
- Transcription factors NFIA and NFIB induce cellular differentiation in high-grade astrocytoma. Chen, K. S., Bridges, C. R., Lynton, Z., Lim, J. W., Stringer, B. W., Rajagopal, R., Ganesan D, … & Richards, L. J.Journal of neuro-oncology 2019
Research on Traumatic Brain Injury
- Management and outcomes following emergency surgery for traumatic brain injury–A multi-centre, international, prospective cohort study (the Global Neurotrauma Outcomes Study). Clark, D., Joannides, A., Abdallah, O. I., Adeleye, A. O., Bajamal, A. H., Bashford, T., Waran V, … & Cherian, I.International journal of surgery protocols 2020
- Cerebral white matter microstructural changes in isolated maxillofacial trauma and associated neuropsychological outcomes. S Sreedharan, V Veeramuthu, F Hariri, N Hamzah, N Ramli, V Narayanan. International Journal of Oral and Maxillofacial Surgery 2020
- Randomised controlled clinical trial of a structured cognitive rehabilitation in patients with attention deficit following mild traumatic brain injury: study protocol. N Hamzah, V Narayanan, N Ramli, Mazlina Mazlan et al. BMJ Open 2019
- Validity and reliability of the Neuropsychological Assessment Battery–Screening Module (S-NAB) in a subset of Malaysian population with mild traumatic brain injury (mTBI). N Hamzah, NA Mohamad, I Thiruselvam, F Hariri, V Veeramuthu, M Mazlan, V Narayanan, N Ramli. Applied Neuropsychology: Adult 2019
- DTI Profiles for Rapid Description of Cohorts at the Clinical-Research Interface. Lock C, Kwok J, Kumar S, Ahmad-Annuar A, Narayanan V, et alFront Med (Lausanne). 2019
Consensus statement from the International Consensus Meeting on the Role of Decompressive Craniectomy in the Management of Traumatic Brain Injury. Hutchinson, P. J., Kolias, A. G., Tajsic, T., Adeleye, A., Aklilu, A. T., Apriawan, T., Waran V … & Bulters, D. Acta neurochirurgica 2019
Research on Spine Surgery
Research on Surgical Innovation and Teaching
- Identifying the sources of error when using 3-dimensional printed head models with surgical navigation. A Mehbodniya, M Moghavvemi, V Narayanan, KA Muthusamy, M Hamdi, V Waran. World neurosurgery 2020
- Frequency and Causes of Line of Sight Issues During Neurosurgical Procedures Using Optical Image-Guided Systems. AH Mehbodniya, M Moghavemi, V Narayanan, V Waran. World neurosurgery 2019
- Telemedicine via Smart Glasses in Critical Care of the Neurosurgical Patient–A COVID-19 Pandemic Preparedness and Response in Neurosurgery. T Munusamy, R Karuppiah, NFA Bahuri, S Sockalingam, CY Cham, V Waran.World Neurosurgery 2020
- Impact of COVID-19 on Neurosurgical Training in Southeast Asia. N Wittayanakorn, VDW Nga, M Sobana, NFA Bahuri, RE Baticulon. World Neurosurgery 2020
- Organ donation innovative strategies for Southeast Asia: ODISSeA. SH Choy, JK Koong, NFA Bahuri, PN Sitaram, D Mohd, AHA Rahim et al.Int J. of Urology 2020
Research on Functional Surgery
- Clinical Phenotype of LRRK2 R1441C in 2 Chinese Sisters. Lim, S. Y., Lim, J. L., Ahmad-Annuar, A., Lohmann, K., Tan, A. H., Lim, K. B., tay Y.W, shing Y.L, Muthusamy K.A., Bauer P, & Rolfs, Neurodegenerative Diseases2020
Research on Skullbase Surgery
- Evolving strategies for resection of sellar/parasellar synchronous tumors via endoscopic endonasal approach-a technical case report and systematic review of the literature. Roethlisberger, M., Jayapalan, R. R., Hostettler, I. C., Kadir, K. A. B. A., Mun, K. S., Brand, Y., … & Waran, V. World neurosurgery 2019
Research on Epilepsy Surgery
- Attitudes toward epilepsy in East Malaysia using the Public Attitudes Toward Epilepsy (PATE) scale. ZJ Chia, KS Lim, SL Fong, RSH Sim, GS Rajahram, V Narayanan, CT Tan. Epilepsy & Behavior 2020
- EEG Source Imaging (ESI) utility in clinical practice. P Khosropanah, ETW Ho, KS Lim, SL Fong, MAT Le, V Narayanan. Biomedical Engineering 2020
- 48-hour video-EEG monitoring for epilepsy presurgical evaluation is cost-effective and safe in resource-limited setting. KS Lim, SL Fong, MAT Le, SA Bazir, V Narayanan, N Ismail, SF Loo, K Krishnan, CT Tan.Epilepsy Research 2020
Research on Paediatric Neurosurgery
- Congenital Hypothyroidism in Children. Zaini, A. A., Tung, Y. F., Bahuri, N. F. A., & Jalaludin, M. Y.Journal of the ASEAN Federation of Endocrine Societies, 2020
- Bridging the Gap in Access to Care for Children With CNS Tumors Worldwide. Moreira, D. C., Rajagopal, R., Navarro-Martin Del Campo, R. M., Polanco, A. C., Alcasabas, A. P., Arredondo-Navarro, L. A., Nor Faizal… & Ganesan, D.JCO Global Oncology 2020
- Analysis of complications following multidisciplinary functional intervention in paediatric craniomaxillofacial deformities. F Hariri, MF Abdullah, KBC Adam, NFA Bahuri, J Kulasegarah et al. International Journal of Oral and Maxillofacial Surgery 2020
Research on Vascular Neurosurgery
- Expression of osteopontin, matrix metalloproteinase-2 and -9 proteins in vascular instability in brain arteriovenous malformation. Anbarasen L, Lim J, Rajandram R, Mun KS, Sia SF.PeerJ 2019
Grants
- UMRG – RP052C-17HTM. Epilepsy Connectomics. A/Prof Vairavan Narayanan 2018-2020
- FRGS- FRGS/1/2019/SKK06/UM/01/1.Lipidomic study of brain cancer cells: An in-vivo study towards understanding the underlying lipogenesis and lipid metabolism regulation gliomas growth. A/Prof Vairavan Narayanan. 2020-2022
- Sciencefund 03-01-03-SF1219. Development of a robotic navigation system for neurology and spine surgery. Prof Vickneswaran Mathaneswaran 2016-2020
- National Neuroscience Institute, Singapore – Brain Connectomics Research Project. A/Prof Vairavan Narayanan 2018-2021
- University of Cambridge. Global Neurotrauma Project. Prof Vickneswaran Mathaneswaran 2019-2022
- IIRG – Tumor Related Epilepsy Project. A/Prof Vairavan Narayanan. 2021-2023
